Key result
Inoculation with the recombinant ASFV-G-DA137R strain completely protected swine from clinical disease and death when challenged with the highly virulent parental ASFV-G strain.
Why the study?
Does deletion of the A137R gene from ASFV-G attenuate the virus and protect swine against virulent challenge?
Does deletion of the A137R gene from ASFV-G attenuate the virus and protect swine against virulent challenge?
Absolute Event Rate: 100% vs 0%
Deletion of the A137R gene from the pandemic ASFV-G strain completely attenuates the virus and provides protection against virulent challenge, making it a promising live attenuated vaccine candidate.
), demonstrating its potential as a vaccine candidate. Therefore, ASFV-G-ΔA137R is a novel experimental ASF vaccine protecting pigs from the epidemiologically relevant ASFV Georgia isolate.
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Gladue et al. (2021) studied African swine fever (n=16). ASFV-G-DA137R vs. ASFV-G (parental virulent strain) or Mock was evaluated on Survival and protection against clinical disease after challenge with virulent ASFV-G. Inoculation with the recombinant ASFV-G-DA137R strain completely protected swine from clinical disease and death when challenged with the highly virulent parental ASFV-G strain.
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