Key result
The addition of resistance training to aerobic training during phase II cardiac rehabilitation significantly decreased PCSK9 levels by 55 ng/ml compared to aerobic training alone in post-CABG patients.
Why the study?
Resistance training is recommended after CABG, but studies investigating its impact on PCSK9 levels were lacking.
Does the addition of resistance training to aerobic training reduce PCSK9 levels in post-CABG patients undergoing phase II cardiac rehabilitation?
RCT (n=87)
Single-blind
Concealed block randomization
No
Does the addition of resistance training to aerobic training reduce PCSK9 levels in post-CABG patients undergoing phase II cardiac rehabilitation?
The addition of resistance training to aerobic training during phase II cardiac rehabilitation significantly reduces PCSK9 levels and improves functional capacity and quality of life in post-CABG patients.
Resistance training lowers PCSK9 post-CABG; extends rehab benefits beyond aerobic training alone.
Background: Resistance training is recommended for post coronary by-pass artery graft (CABG) patients in addition to aerobic training as part of secondary prevention. However, there is a lack of studies that investigate the impact of resistance training on proprotein convertase subtilisin kexin 9 (PCSK9). Aim: This study aims to assess the impact of intensive resistance training on PCSK9 level in post-CABG patients undergoing phase II cardiac rehabilitation. Methods: In this randomized, prospective, open label trial, 87 postCABG patients were assigned to moderate to high intensity resistance training and aerobic training (n=44) and aerobic training only (n=43) for 34 weeks. The primary endpoint was change of PCSK9 levels after cardiac rehabilitation program. Secondary endpoints include change of six-minute walk test (6-MWT) result, aerobic capacity, WHO5 wellbeing index, fasting blood glucose and lipid profile. Intention-to-treat analysis was performed in both groups. Results: After completion of phase II cardiac rehabilitation, mean PCSK9 levels in intervention group decreased significantly compared to control group (β=55 ng/ml, 95%CI 6.7 to 103.3, p=0.026). This reduction was followed by significant improvement of 6-MWT result (β=28.2 m, 95%CI 2.4-53.9, p=0.033), aerobic capacity (β=0.9 Mets, 95%CI 0.1-1.7, p=0.021), and WHO5 wellbeing index (β=8.1, 95%CI 2.0-14.4, p=0.011) in patients who performed resistance training in addition to aerobic training. There are no significant changes in fasting blood glucose, cholesterol, LDLC, HDL-C, and triglyceride. Conclusion: The addition of resistance training to aerobic training components in phase II cardiac rehabilitation significantly reduces PCSK9 levels and increases patient’s functional capacity and quality of life. (NCT02674659)
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Dwiputra et al. (2023) conducted an RCT in Post-coronary artery bypass grafting (CABG) (n=87). Resistance training and aerobic training vs. Aerobic training only was evaluated on Change in PCSK9 levels after cardiac rehabilitation program (β = -55 ng/ml, 95% CI -103.3 to -6.7, p=0.026). The addition of resistance training to aerobic training during phase II cardiac rehabilitation significantly decreased PCSK9 levels by 55 ng/ml compared to aerobic training alone in post-CABG patients.
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