Key result
Resistance training combined with aerobic training significantly reduced mean PCSK9 levels by 55 ng/ml compared to aerobic training alone in post-CABG patients undergoing cardiac rehabilitation.
Why the study?
Resistance training is commonly recommended after CABG, but studies investigating its impact on PCSK9 levels are lacking.
Does adding resistance training to aerobic training reduce PCSK9 levels in post-CABG patients undergoing cardiac rehabilitation?
RCT (n=87)
Open-label
Concealed block randomization
No
Does adding resistance training to aerobic training reduce PCSK9 levels in post-CABG patients undergoing cardiac rehabilitation?
Adding resistance training to aerobic exercise during cardiac rehabilitation significantly reduces PCSK9 levels and improves functional capacity in post-CABG patients.
Intensive resistance training was associated with lower PCSK9 post-CABG; hypothesis-generating and requires confirmation in RCTs before practice change.
BACKGROUND: Resistance training is commonly recommended as part of secondary prevention for post-coronary artery bypass graft (CABG) patients in conjunction with aerobic exercise. Despite its potential benefits, there is currently a lack of studies investigating the impact of resistance training on proprotein convertase subtilisin kexin 9 (PCSK9). AIM: To evaluate the effect of intensive resistance training on proprotein convertase subtilisin kexin 9 (PCSK9) levels among post-CABG patients undergoing cardiac rehabilitation (CR). METHODS: In this prospective, open-label, randomized trial, 87 post-coronary artery bypass graft (CABG) patients were randomly assigned into two groups: moderate to high intensity resistance training and aerobic training (n = 44) or aerobic training alone (n = 43) for a total of 12 sessions. Changes in PCSK9 levels was determined as a primary endpoint, while secondary endpoints included changes in the six-minute walk test (6-MWT) results, aerobic capacity, WHO-5 well-being index, fasting blood glucose, and lipid profile. Both groups underwent intention-to-treat analysis. RESULTS: Following completion of cardiac rehabilitation program, the intervention group demonstrated a significant decrease in mean PCSK9 levels when compared to the control group (β = -55 ng/ml, 95% CI -6.7 to -103.3, p = 0.026), as well as significant improvements in the 6-MWT result (β = 28.2 m, 95% CI 2.4-53.9, p = 0.033), aerobic capacity (β = 0.9 Mets, 95% CI 0.1-1.7, p = 0.021), and WHO-5 well-being index (β = 8.1, 95% CI 2.0-14.4, p = 0.011) in patients who received resistance and aerobic training. No statistically significant changes were observed in fasting blood glucose, cholesterol, LDL-C, HDL-C, and triglyceride levels. CONCLUSION: Resistance training in CR significantly reduced PCSK-9 levels and increases patient's functional capacity and quality of life. (NCT02674659 04/02/2016).
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Dwiputra et al. (2023) conducted an RCT in Post-coronary artery bypass graft (CABG) (n=87). Resistance training and aerobic training vs. Aerobic training alone was evaluated on Changes in PCSK9 levels (β = -55 ng/ml, 95% CI -103.3 to -6.7, p=0.026). Resistance training combined with aerobic training significantly reduced mean PCSK9 levels by 55 ng/ml compared to aerobic training alone in post-CABG patients undergoing cardiac rehabilitation.
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