June 1, 2014Memórias do Instituto Oswaldo CruzOpen Access

Severity of chronic experimental Chagas' heart disease parallels tumour necrosis factor and nitric oxide levels in the serum: models of mild and severe disease

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Structured PICO

Population

C3H/He and C57BL/6 mice chronically infected with the Colombian Trypanosoma cruzi strain

Intervention

Infection with Trypanosoma cruzi (Colombian strain)

Comparator

Comparison between C3H/He mice and C57BL/6 mice

Outcome

Cardiac parasitism, inflammation, connexin 43 disorganisation, fibronectin deposition, creatine kinase cardiac MB isoenzyme activity, electrical abnormalities, and serum TNF and NO levelssurrogate

C3H/He and C57BL/6 mice infected with T. cruzi serve as severe and mild models of chronic chagasic cardiomyopathy, with disease severity paralleling serum TNF and NO levels.

Discussion

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Implication

Enables mechanistic studies of TNF/NO in strain-dependent CCC; leaves open clinical translation.

Cite This Study

Pereira et al. (2014) studied this question.

synapsesocial.com/papers/6a75eeb759d67b3b928b73d8 https://doi.org/10.1590/0074-0276140033

View Full Paper

Ask AI

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Severity of chronic experimental Chagas' heart disease parallels tumour necrosis factor and nitric oxide levels in the serum: models of mild and severe disease

Structured PICO

Discussion

Implication

Cite This Study

Severity of chronic experimental Chagas' heart disease parallels tumour necrosis factor and nitric oxide levels in the serum: models of mild and severe disease

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider