Key result
Combined prophylaxis with low-molecular-weight heparin and intermittent pneumatic compression reduced the incidence of deep vein thrombosis to 0% compared to 23.4% in the control group.
Why the study?
Does combined LMWH and IPC reduce DVT in critically ill trauma patients compared to either treatment alone or no prophylaxis?
Population
500 critically ill trauma patients with severe injuries
Comparison
Intermittent pneumatic compression alone… vs Control group receiving no IPC treatment or…
Design
Cohort
Authors
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May support combined DVT prophylaxis; hypothesis-generating and should not change practice without randomized confirmation.
Observational (n=500)
No
Does combined LMWH and IPC reduce DVT in critically ill trauma patients compared to either treatment alone or no prophylaxis?
Absolute Event Rate: 0% vs 23.4%
p-value: p=<0.01
Combined LMWH and IPC appears more effective than either treatment alone for DVT prophylaxis in critically ill trauma patients at high risk for VTE (Wells score ≥3).
Wan et al. (2015) conducted an observational in Critically ill patients at risk for venous thromboembolism (n=500). Low-molecular-weight heparin (LMWH) combined with intermittent pneumatic compression (IPC) vs. No prophylaxis (control), IPC alone, or LMWH alone was evaluated on Incidence of deep vein thrombosis (DVT) (p=<0.01). Combined prophylaxis with low-molecular-weight heparin and intermittent pneumatic compression reduced the incidence of deep vein thrombosis to 0% compared to 23.4% in the control group.
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