Key result
Intermittent pneumatic compression reduces VTE incidence ~65% vs no thromboprophylaxis in critically ill patients.
Why the study?
VTE is a common complication in critically ill patients and IPC is recommended for those at high bleeding risk, but its effectiveness for thromboprophylaxis required evaluation.
Does intermittent pneumatic compression reduce the incidence of venous thromboembolism in critically ill patients?
Population
Critically ill patients across 10 included studies
Comparison
IPC vs no thromboprophylaxis, GCS, LMWH, or as adjunctive treatment
Design
Systematic review and meta-analysis of RCTs and observational studies
Authors
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Supports IPC for VTE prophylaxis in critically ill patients; reinforces Level 1 evidence and supports guideline consideration versus no prophylaxis.
Meta-Analysis
Does intermittent pneumatic compression reduce the incidence of venous thromboembolism in critically ill patients?
Relative Risk: 0.35 (95% CI 0.18–0.68)
p-value: p=.002
Intermittent pneumatic compression is an effective thromboprophylaxis strategy in critically ill patients, superior to graduated compression stockings and no prophylaxis, and similar in efficacy to LMWH but with less bleeding.
Wang et al. (2020) conducted a meta-analysis in Venous thromboembolism in critically ill patients. Intermittent pneumatic compression vs. No thromboprophylaxis was evaluated on VTE incidence (RR 0.35, 95% CI 0.18-0.68, p=.002). Intermittent pneumatic compression significantly reduced VTE incidence in critically ill patients compared with no thromboprophylaxis (RR 0.35; 95% CI 0.18-0.68; P=.002).
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