Population
Normal rabbits and rabbits fed cholesterol for approximately 8 days
Comparison
Cholesterol feeding for approximately 8 days vs Normal diet (normal rabbits)
Design
Preclinical
Follow-up
8 days
Authors
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No immediate clinical implications; leaves open whether regional LDL transport differences drive human atherosclerosis susceptibility.
Differences in arterial LDL transport and metabolism provide a mechanistic explanation for the varying susceptibility to atherosclerosis across different arterial regions.
Dawn C. Schwenke (1997) studied this question.
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