Why the study?
Do dobutamine stress echocardiography and exercise mibi-SPECT improve diagnostic accuracy for coronary artery disease compared to exercise ECG in patients with chest pain?
Do dobutamine stress echocardiography and exercise mibi-SPECT improve diagnostic accuracy for coronary artery disease compared to exercise ECG in patients with chest pain?
Dobutamine stress echocardiography and exercise mibi-SPECT provide superior diagnostic accuracy for coronary artery disease compared to standard exercise ECG, with dobutamine echocardiography serving as a highly accurate, non-radioactive alternative to SPECT.
Supports preferring dobutamine echo or mibi-SPECT over exercise ECG for CAD diagnosis; hypothesis-generating pending prospective validation.
To compare the value of exercise electrocardiography with dobutamine stress echocardiography and exercise technetium-99m isonitrile single-photon emission computed tomography for coronary artery disease, 70 patients with either suspected or proven coronary artery disease underwent dobutamine stress echocardiography, exercise technetium-99m isonitrile single-photon emission computed tomography (mibi-SPECT) and treadmill exercise electrocardiography (ECG). Dobutamine echocardiography and exercise mibi-SPECT revealed a higher overall sensitivity than exercise testing (90 vs 57%, p < 0.001; 96 vs 57%, p < 0.001, respectively). Dobutamine stress echocardiography showed a higher specificity than both exercise mibi-SPECT and treadmill exercise electrocardiography (90 vs 71%, p > 0.05; 90 and 62% p < 0.05, respectively) but the difference between dobutamine stress echocardiography and exercise mibi-SPECT was not statistically significant. Diagnostic accuracy of dobutamine stress echocardiography and exercise mibi-SPECT was higher than that of exercise testing (90 vs 59%, p < 0.001; 89 vs 59%, p < 0.001, respectively). Dobutamine stress echocardiography and exercise mibi-SPECT have superiority over exercise testing in the diagnosis of coronary artery disease and dobutamine stress echocardiography is an alternative for exercise mibi-SPECT.
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Oğuzhan et al. (1997) studied this question.
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