Why the study?
Does long-term imipramine treatment alter the heart rate and blood pressure response to standing compared to a single large dose in normal subjects?
Does long-term imipramine treatment alter the heart rate and blood pressure response to standing compared to a single large dose in normal subjects?
The heart rate response to standing may serve as a useful index of neuropharmacological adaptation during therapeutic tricyclic antidepressant administration.
Suggests orthostatic tolerance develops with chronic imipramine; leaves open standing heart rate response as adaptation index pending prospective studies.
The heart rate and blood pressure response to standing in eight patients receiving imipramine treatment for panic disorder were compared with the same measures in eight normal subjects after a single large dose. Despite higher plasma drug levels, patients on long‐term medication had a less abnormal orthostatic response than volunteers. This suggests that the heart rate response to standing could be a useful index of the neuropharmacological adaptation known to occur during administration of therapeutic doses of tricyclic antidepressant.
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Middleton et al. (1988) studied this question.
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