Key result
Surgical tumour resection followed by chemoradiation therapy resulted in 3-year survival without tumour regrowth or metastasis in a 56-year-old woman with primary cardiac sarcoma after breast cancer.
Case Report (n=1)
Surgical resection and chemoradiation can provide long-term survival in patients with postradiation primary cardiac sarcoma, despite challenges from prior cancer therapies.
Answers are grounded in this paper and cite their sources.
May support multimodal therapy consideration in rare postradiation cardiac sarcomas; leaves open need for prospective data before practice change.
Primary cardiac sarcomas are rare tumours carrying poor prognosis. Postradiation sarcoma has been reported in patients with breast, cervical and head and neck cancers. We report a case of a 56-year-old woman with stage IIA breast cancer diagnosed in 1997, submitted to mastectomy, adjuvant chemotherapy, radiotherapy and hormonotherapy. Pulmonary metastasis were detected in 2008 and treated with chemotherapy and hormonotherapy, being in complete remission since August 2009. She was admitted in December 2009 with a 3-week history of fever, dyspnoea, polyarthralgias and leg oedema. An echocardiography showed a mass in the left atrium. She was submitted to a surgical tumour resection and the histology revealed a sarcoma of intermediate degree of differentiation. Chemoradiation therapy was started and she remains alive after 3 years, without tumour regrowth or metastasis. This case is a therapeutic challenge, because the previous therapies for breast cancer hampered the options for extra chemoradiation therapy.
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Ramalho et al. (2013) conducted a case report in Primary cardiac sarcoma after breast cancer (n=1). Surgical tumour resection and chemoradiation therapy was evaluated on Survival without tumour regrowth or metastasis. Surgical tumour resection followed by chemoradiation therapy resulted in 3-year survival without tumour regrowth or metastasis in a 56-year-old woman with primary cardiac sarcoma after breast cancer.
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