What question did this study set out to answer?

To evaluate the effects of propafenone on left ventricular function and hemodynamics in patients with congestive heart failure.

December 1, 1987Journal of Electrophysiology

Hemodynamic Effect of Propafenone and the Experience in Patients with Congestive Heart Failure

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Why the study?

Does propafenone affect left ventricular ejection fraction in patients with congestive heart failure?

Population

27 patients, including patients with congestive heart failure.

Comparison

Propafenone vs Baseline (pre-therapy measurements)

Design

Cohort

Authors

BBBonnie J. BakerProvidence College MBMichael A. BrodskyMontefiore Medical Center HDHa DinhUniversity of Arkansas for Medical Sciences

Discussion

Member takes

Implication

May reduce LVEF during titration in HF patients; hypothesis-generating, requiring RCTs before practice change.

Key Points

To evaluate the effects of propafenone on left ventricular function and hemodynamics in patients with congestive heart failure.
Measured left ventricular ejection fraction via nuclear study before and during chronic oral propafenone therapy in 8 of 13 patients undergoing electrophysiological testing.
Conducted a separate dose-titration protocol in 14 patients to assess acute hemodynamic changes.
Chronic therapy produced no statistically significant difference in left ventricular ejection fraction, with baseline values ranging from 22% to 39% (mean 30%) and post-treatment values ranging from 22% to 48% (mean 30%).
Dose titration resulted in a modest but statistically significant decrease in left ventricular ejection fraction from 52% ± 9% to 48% ± 11% (p < 0.05), an effect that was more pronounced in patients with lower baseline function.

Structured PICO

Does propafenone affect left ventricular ejection fraction in patients with congestive heart failure?

Population

27 patients (13 undergoing electrophysiological testing and chronic oral propafenone therapy, 14 in a dose titration study), including patients with congestive heart failure.

Intervention

Propafenone (chronic oral therapy or dose titration)

Comparator

Baseline (pre-therapy measurements)

Outcome

Left ventricular ejection fraction determined by nuclear studysurrogate

Propafenone causes a modest decrease in left ventricular ejection fraction, particularly in patients with initially low ejection fractions, warranting caution in heart failure patients.

Cite This Study

Baker et al. (1987) studied this question.

synapsesocial.com/papers/6a75f59474b63c188eb209b7 https://doi.org/10.1111/j.1540-8167.1987.tb01444.x

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Hemodynamic Effect of Propafenone and the Experience in Patients with Congestive Heart Failure

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Hemodynamic Effect of Propafenone and the Experience in Patients with Congestive Heart Failure

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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