Why the study?
Is hypertension associated with an increased prevalence of late ventricular potentials in patients with normal coronary arteries?
Is hypertension associated with an increased prevalence of late ventricular potentials in patients with normal coronary arteries?
Late ventricular potentials, a marker for ventricular arrhythmias, are significantly more common in hypertensive patients with normal coronary arteries than in normotensive controls.
Hypertension was associated with late ventricular potentials; hypothesis-generating and should not change practice pending prospective studies.
Late ventricular potentials detected by signal averaging are used for predicting ventricular arrhythmias and sudden cardiac death in patients with coronary artery disease. We studied the prevalence of signal-averaged late ventricular potentials in 37 male patients (mean age of 56 years) with angiographically normal coronary arteries. Seventeen patients were hypertensive (group A) and 20 patients were normotensive (group B). In group A, 5 of 17 patients (29%) had late ventricular potentials. In group B, only 1 of 20 patients (5%) had late potentials (p less than 0.05). Late ventricular potentials detected by signal averaging are more common in hypertensive patients than in healthy controls. Whether late ventricular potentials can be used to predict malignant ventricular arrhythmias or sudden cardiac death in hypertensive patients will have to be investigated in further studies.
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Brune et al. (1991) studied this question.
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