Differences in tyrosine hydroxylase-like immunoreactivity characterize the mesostriatal innervation of striosomes and extrastriosomal matrix at maturity.
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Discussion
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Implication
Comparative neuroanatomical study reveals lower tyrosine hydroxylase immunoreactivity in striosomes than in the matrix across mature mammalian brains, suggesting compartmentalized dopamine regulation.
Key Points
- To determine the anatomical distribution of tyrosine hydroxylase-positive dopaminergic fibers within the striosomal and extrastriosomal compartments of the mature mammalian striatum.
- Examined postmortem striatal tissue, specifically the caudate nucleus and putamen, from mature humans, monkeys, and cats.
- Used three distinct polyclonal antibodies against tyrosine hydroxylase, with antibody specificity validated via two-dimensional gel electrophoresis.
- Tyrosine hydroxylase-like immunoreactivity showed a distinctly inhomogeneous distribution across the mature striatum.
- Striosomal compartments consistently exhibited lower tyrosine hydroxylase-like immunoreactivity relative to the surrounding extrastriosomal matrix across all examined species.
Cite This Study
Graybiel et al. (1987) studied this question.