Why the study?
Does elevated aortic pressure accelerate ribosomal protein synthesis in rat hearts?
Does elevated aortic pressure accelerate ribosomal protein synthesis in rat hearts?
Elevation of aortic pressure preferentially increases the synthesis of new ribosomes, representing an early event in cardiac hypertrophy.
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May initiate hypertrophy via ribosomal biogenesis in rodent models; leaves open relevance to human pressure overload.
Chua et al. (1987) studied this question.
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