July 1, 1991Pacing and Clinical Electrophysiology

Dispersion of Repolarization Induced by a Nonuniform Shock Field

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Population

Bathed frog ventricular strips

Comparison

5 ms rectangular electrical field stimulus with… vs Uniform S2 of 1 V/cm

Design

Preclinical

Follow-up

60-80 minutes

Authors

SKStephen B. KnisleyUniversity of North Carolina at Chapel Hill YAYohannes AfeworkJohns Hopkins University JLJianhua LiKunming University of Science and Technology

Discussion

Member takes

Implication

Nonuniform shocks may induce repolarization dispersion in ventricular tissue; hypothesis-generating for proarrhythmia mechanisms in clinical defibrillation.

Structured PICO

Population

Bathed frog ventricular strips

Intervention

5 ms rectangular electrical field stimulus (S2) with a nonuniform potential gradient (39 +/- 11 V/cm in one half [H], 0.3 +/- 0.2 V/cm in the other half [L]) applied during the action potential

Comparator

Uniform S2 of 1 V/cm

Outcome

Action potential duration and dispersion of repolarizationsurrogate

Nonuniform electrical shocks can induce a dispersion of repolarization and may cause cell-to-cell interactions during repolarization in ventricular tissue.

Cite This Study

Knisley et al. (1991) studied this question.

synapsesocial.com/papers/6a75fca774b63c188eb20c81 https://doi.org/10.1111/j.1540-8159.1991.tb02846.x

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Implication

Nonuniform shocks may induce repolarization dispersion in ventricular tissue; hypothesis-generating for proarrhythmia mechanisms in clinical defibrillation.

Dispersion of Repolarization Induced by a Nonuniform Shock Field

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Dispersion of Repolarization Induced by a Nonuniform Shock Field

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider