Why the study?
Little is known regarding glucocorticoid receptor genome-binding and dependent transcriptional changes that mediate glucocorticoid-induced cardiomyocyte hypertrophy.
Population
Isolated cardiomyocytes and in vivo models
Comparison
1 and 24 hours of dexamethasone treatment
Design
Preclinical high-resolution sequencing study
Follow-up
24 hours
Authors
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GR signaling insights in hypertrophy models may guide future targets; leaves open clinical translation in heart failure.
Dexamethasone induces cardiomyocyte hypertrophy through specific glucocorticoid receptor genome-binding and transcriptome changes.
Severinova et al. (2019) studied this question.
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