Population
HL-1 cardiomyocytes and gene targeted mice lacking functional Sgk1 and respective wild type mice
Comparison
Dexamethasone treatment vs Untreated controls and sgk1-/- mice
Design
Preclinical
Authors
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Sgk1-dependent Nhe1 activation by dexamethasone in mice is hypothesis-generating; leaves open any role in human cardiac remodeling or therapy.
Sgk1 is critically involved in the dexamethasone-induced phosphorylation and activation of the cardiac Na+/H+ exchanger Nhe1, which may contribute to cardiac remodeling.
Voelkl et al. (2013) studied this question.
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