Population
Rabbit alveolar macrophages in culture
Comparison
Dexamethasone and prednisone (4 nM steroid) vs Control
Design
Preclinical
Follow-up
3 days
Authors
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Hypothesis-generating for glucocorticoid-ACE interactions in macrophages; leaves open relevance to blood pressure regulation in vivo.
Steroids induce angiotensin converting enzyme in rabbit alveolar macrophages via de novo transcription and enzyme synthesis, suggesting a regulatory mechanism relevant to blood pressure control.
Friedland et al. (1977) studied this question.
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