May 1, 2013Journal of Managed Care PharmacyOpen Access

One-Year Adherence to Warfarin Treatment for Venous Thromboembolism in High-Risk Patients and Its Association with Long-term Risk of Recurrent Events

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Why the study?

Does noncompliance or discontinuation of warfarin therapy increase the risk of recurrent VTE in high-risk patients?

Population

8,040 adult patients at high risk of recurrent VTE who filled a warfarin prescription within 2 weeks of an…

Comparison

Noncompliance or discontinuation of warfarin… vs Compliance or continuation of warfarin therapy…

Design

Cohort

Follow-up

Until patients were lost to follow-up after the 1-year…

Authors

SCShih‐Yin ChenLuminex (United States)NWNing WuPeking University MGMichael P. GulsethSanford USD Medical Center

Discussion

Member takes

Implication

Supports monitoring warfarin adherence to potentially reduce VTE recurrence; leaves open whether targeted interventions improve outcomes in high-risk patients.

Structured PICO

Does noncompliance or discontinuation of warfarin therapy increase the risk of recurrent VTE in high-risk patients?

Population

8,040 adult patients at high risk of recurrent VTE (with cancer, or noncancer without reversible risk factors in the prior 3 months) who filled a warfarin prescription within 2 weeks of an index VTE event, mean age 61 years, 59.4% male.

Intervention

Noncompliance (proportion of days covered < 0.8) or discontinuation (90-day gap in supply) of warfarin therapy over a 1-year assessment period.

Comparator

Compliance (proportion of days covered ≥ 0.8) or continuation of warfarin therapy over a 1-year assessment period.

Outcome

Recurrent VTE events (hospitalizations where VTE was the primary diagnosis) occurring after the 1-year assessment period.hard clinical

In high-risk VTE patients, noncompliance and discontinuation of warfarin therapy over a 1-year period are common and associated with a significantly higher risk of recurrent VTE.

Cite This Study

Chen et al. (2013) studied this question.

synapsesocial.com/papers/6a75fdb3c14fe0c475707e83 https://doi.org/10.18553/jmcp.2013.19.4.291

Topics

Anticoagulation in AF

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Implication

Supports monitoring warfarin adherence to potentially reduce VTE recurrence; leaves open whether targeted interventions improve outcomes in high-risk patients.

One-Year Adherence to Warfarin Treatment for Venous Thromboembolism in High-Risk Patients and Its Association with Long-term Risk of Recurrent Events

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

One-Year Adherence to Warfarin Treatment for Venous Thromboembolism in High-Risk Patients and Its Association with Long-term Risk of Recurrent Events

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

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