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January 4, 2023Food Science & NutritionOpen Access

LSD significantly reduced SBP (WMD: −3.79 mmHg, 95% CI: −6.02, −1.56) and DBP (WMD: −1.62 mmHg, 95% CI: −2.84, −0.40) in comparison with HSD, but had no significant effect on MAP.

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Why the study?

Numerous clinical trials had investigated sodium intake on blood pressure in diabetic patients, prompting an evaluation of clinical trial evidence comparing low versus high sodium diets.

Does a low sodium diet reduce blood pressure in diabetic patients compared to a high sodium diet?

Population

Patients with type 1 and 2 diabetes across 15 clinical trials

Comparison

Low sodium diet vs high sodium diet

Design

Systematic review and random-effects meta-analysis of clinical trials

Authors

MGMahsa Gholizadeh‐MoghaddamFSFarnaz ShahdadianFSFatemeh Shirani

Discussion

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Member takes

Overview

Low-sodium diet lowers SBP and DBP in diabetes; reinforces sodium restriction as adjunctive therapy in guidelines.

Structured PICO

Does a low sodium diet reduce blood pressure in diabetic patients compared to a high sodium diet?

P
Population
Diabetic patients (type 1 and 2) from 15 clinical trials
I
Intervention
Low sodium diet (LSD)
C
Comparator
High sodium diet (HSD)
O
Outcome
Systolic blood pressure (SBP) and diastolic blood pressure (DBP)surrogate

A low sodium diet significantly reduces systolic and diastolic blood pressure in patients with type 1 and type 2 diabetes compared to a high sodium diet.

Limitations

  • Heterogeneity in SBP could not be attenuated by subgroup analysis

Cite This Study

Gholizadeh‐Moghaddam et al. (2023) studied this question.

synapsesocial.com/papers/6a75fdfbf56d87d9178b7aa4https://doi.org/10.1002/fsn3.3212
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