Key result
Low-sodium salt substitutes lower SBP by ~8 mm Hg and decrease DBP versus regular salt.
Why the study?
The study was conducted to assess the efficacy of low-sodium salt substitutes as a potential intervention to reduce cardiovascular diseases.
Do low-sodium salt substitutes reduce blood pressure and cardiovascular events in adult hypertensive or general populations compared with regular salt?
Population
21 RCTs (15 in hypertensive [n=2016], 2 in normotensive [n=163], and 4 in mixed populations [n=5224])
Comparison
Low-sodium salt substitutes versus regular salt
Design
Systematic review and meta-analysis of randomised controlled trials
Authors
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Supports recommending low-sodium salt substitutes for BP control; confirms efficacy across randomized trials.
Meta-Analysis (n=7,403)
Do low-sodium salt substitutes reduce blood pressure and cardiovascular events in adult hypertensive or general populations compared with regular salt?
Mean Difference: -7.81 (95% CI -9.47–-6.15)
p-value: p=<0.00001
Low-sodium salt substitutes effectively lower systolic and diastolic blood pressure, though evidence for hard clinical outcomes like mortality remains inconclusive.
Hernández et al. (2019) conducted a meta-analysis in Hypertension or general population (n=7,403). Low-sodium salt substitutes (LSSS) vs. Regular salt was evaluated on Systolic blood pressure (SBP) (MD -7.81 mm Hg, 95% CI -9.47 to -6.15, p=<0.00001). Low-sodium salt substitutes significantly decreased systolic blood pressure (MD -7.81 mm Hg; 95% CI -9.47 to -6.15; p<0.00001) and diastolic blood pressure compared with regular salt.
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