The Effect of Diabetes On Lysyl Oxidase Activity and Extractability of Newly Synthesized Collagen in Rat Gingiva and Skin¹

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Lysyl oxidase activity and the extractability of recently synthesized collagen were measured in gingiva and skin, two tissues which exhibit altered pathophysiologic responses during diabetes. Both tissues showed a reduced content and extractability of newly synthesized, 14 C‐Hydroxyproline labeled, collagen after induction of streptozotocin‐induced diabetes. Diabetes increased lysyl oxidase activity in skin and gingiva but the effect on gingiva was much less dramatic. The altered characteristics of interstitial collagen in the diabetic rat, including aging‐like changes, appear to reflect multiple alterations in collagen metabolism.