November 9, 2005FEBS JournalOpen Access

Cardiac troponin C‐L29Q, related to hypertrophic cardiomyopathy, hinders the transduction of the protein kinase A dependent phosphorylation signal from cardiac troponin I to C

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Structured PICO

Population

In vitro protein models of cardiac troponin C (cTnC) with the L29Q mutation associated with hypertrophic cardiomyopathy

Intervention

L29Q mutation in TNNC1 (cTnC)

Comparator

Wild-type cardiac troponin

Outcome

Structural and functional changes including cTnI-cTnC interaction, calcium sensitivity, actoS1-ATPase activity, and sliding velocity of thin filamentssurrogate

The L29Q mutation in cardiac troponin C alters calcium sensitivity and hinders PKA-dependent phosphorylation signal transduction, providing a molecular mechanism for its role in hypertrophic cardiomyopathy.

Discussion

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Implication

Animal data on L29Q warrant no change in HCM care; leaves open clinical relevance and requires human validation.

Cite This Study

Schmidtmann et al. (2005) studied this question.

synapsesocial.com/papers/6a7606db67b8a7e54870776b https://doi.org/10.1111/j.1742-4658.2005.05001.x

Topics

Hypertrophic cardiomyopathy

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Cardiac troponin C‐L29Q, related to hypertrophic cardiomyopathy, hinders the transduction of the protein kinase A dependent phosphorylation signal from cardiac troponin I to C

Structured PICO

Discussion

Implication

Cite This Study

Topics

Cardiac troponin C‐L29Q, related to hypertrophic cardiomyopathy, hinders the transduction of the protein kinase A dependent phosphorylation signal from cardiac troponin I to C

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider