Population
Humans and swine genetically predisposed to malignant hyperthermia
Design
Review
Authors
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RYR1 screening may aid MH risk stratification; leaves open complete mapping of heterogeneous human variants beyond swine models.
Malignant hyperthermia is linked to mutations in the ryanodine receptor gene (RYR1), though the genetic basis in humans is heterogeneous compared to swine.
MacLennan et al. (1992) studied this question.
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