November 1, 2000Journal of the American Society of Nephrology

Evidence of Gene—Gene Interactions in the Genetic Susceptibility to Renal Impairment after Unilateral Nephrectomy

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Population

337 animals in an F2 intercross of genetically hypertensive fawn-hooded rats

Design

Preclinical

Follow-up

8 weeks

Authors

MSMasahide ShiozawaUniversity of Iowa APAbraham P. ProvoostErasmus University Rotterdam RDRichard P.E. van DokkumUniversity Medical Center Groningen

Discussion

Member takes

Implication

Findings remain preclinical and should not guide hypertension care; leaves open polygenic renal impairment mechanisms for future study.

Structured PICO

Population

337 animals in an F2 intercross of genetically hypertensive fawn-hooded rats

Intervention

Total genome scan (418 markers) to identify regions contributing to the pathogenesis of progressive proteinuria (UPV) and focal glomerulosclerosis (FGS) after unilateral nephrectomy

Outcome

Genetic loci involved in the development of renal impairment (systolic BP, UPV, albuminuria, and FGS) at 8 weeks after unilateral nephrectomysurrogate

Multiple interacting genetic loci, along with blood pressure, contribute to the development of progressive renal failure in a hypertensive rat model.

Cite This Study

Shiozawa et al. (2000) studied this question.

synapsesocial.com/papers/6a7609c5d5b06e2c1e613c11 https://doi.org/10.1681/asn.v11112068

View Full Paper

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Evidence of Gene—Gene Interactions in the Genetic Susceptibility to Renal Impairment after Unilateral Nephrectomy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Evidence of Gene—Gene Interactions in the Genetic Susceptibility to Renal Impairment after Unilateral Nephrectomy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider