March 1, 1998Journal of the American Society of Nephrology

Genetic differences define severity of renal damage after L-NAME-induced hypertension in rats.

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Population

Heterozygous F1 rats, parental hypertensive and proteinuric fawn-hooded Erasmus University Rotterdam rats…

Comparison

Chronic treatment with NG-nitro-L-arginine… vs Comparison between the three rat strains at…

Design

Preclinical

Authors

RDRichard Pe van DokkumUniversity of Groningen HJHoward J. JacobCross-Cutting Cardiology APA. P. ProvoostCentre Hospitalier Universitaire de Reims

Discussion

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Implication

Genetic predisposition may outweigh BP level in driving hypertensive renal injury in rat models; leaves open translation to human CKD.

Structured PICO

Population

Heterozygous (FHH X ACI) F1 rats, parental hypertensive and proteinuric fawn-hooded Erasmus University Rotterdam (FHH/EUR) rats, and normotensive, nonproteinuric August Copenhagen Irish (ACI/EUR) rats

Intervention

Chronic treatment with NG-nitro-L-arginine methyl ester (L-NAME) in either a low dose (75 to 100 mg/L) or a high dose (175 to 250 mg/L) in the drinking fluid

Comparator

Comparison between the three rat strains (F1, FHH, ACI) at similar levels of systolic blood pressure

Outcome

Functional renal damage (level of albuminuria) and structural renal damage (incidence of glomerulosclerosis)surrogate

Susceptibility to hypertension-associated renal damage in rats primarily depends on the presence of predisposing genes for renal failure, even after a significant increase in blood pressure.

Cite This Study

Dokkum et al. (1998) studied this question.

synapsesocial.com/papers/6a86adb3ddd5671cb07cac52 https://doi.org/10.1681/asn.v93363

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Genetic differences define severity of renal damage after L-NAME-induced hypertension in rats.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Genetic differences define severity of renal damage after L-NAME-induced hypertension in rats.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider