Key result
Transfer of chromosome 1 from the Brown Norway rat to the fawn-hooded hypertensive background attenuated L-NAME-induced hypertension (MAP 167 vs 188 mmHg) and reduced glomerular damage.
Why the study?
Does the transfer of chromosome 1 from BN rats to FHH rats ameliorate L-NAME-induced hypertension and renal disease?
Population
Conscious male and female rats maintained for 2 weeks on 8.0% NaCl chow with NG-nitro-L-arginine methyl…
Comparison
Transfer of chromosome 1 from the Brown Norway… vs FHH rats and BN rats.
Design
Preclinical
Follow-up
2 weeks
Authors
Loading...
Implicates chromosome 1 loci in L-NAME hypertension and glomerular injury; leaves open causal variants and human translation.
Does the transfer of chromosome 1 from BN rats to FHH rats ameliorate L-NAME-induced hypertension and renal disease?
Absolute Event Rate: 167% vs 188%
Genes contributing to L-NAME-induced hypertension and renal disease are located on chromosome 1 of the fawn-hooded hypertensive rat.
Mattson et al. (2005) studied Hypertension and renal disease. Transfer of chromosome 1 from the Brown Norway rat to the FHH genetic background (FHH-1BN) vs. FHH rats and BN rats was evaluated on Mean arterial blood pressure (MAP). Transfer of chromosome 1 from the Brown Norway rat to the fawn-hooded hypertensive background attenuated L-NAME-induced hypertension (MAP 167 vs 188 mmHg) and reduced glomerular damage.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: