Why the study?
Does genetic strain affect the susceptibility to developing renal damage after L-NAME induced hypertension in rats?
Population
Male normotensive fawn-hooded (FHL) and August × Copenhagen Irish (ACI) rats
Comparison
Chronic treatment with N-nitro-L-arginine methyl… vs Comparison between the two strains (FHL vs ACI)
Design
Preclinical
Follow-up
11 weeks
Authors
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Suggests genetic modifiers of hypertensive renal injury in rats; leaves open human translation and clinical risk stratification.
Does genetic strain affect the susceptibility to developing renal damage after L-NAME induced hypertension in rats?
Genetic factors significantly influence the susceptibility to hypertension-induced renal damage, as demonstrated by the increased vulnerability of FHL rats compared to ACI rats.
Richard P.E. van Dokkum (1997) studied this question.
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