Key result
Transfer of a 4.3-Mb region of BN chromosome 1 into the FHH genetic background improved autoregulation of renal blood flow, normalized glomerular capillary pressure, and slowed renal disease progression.
Population
Fawn Hooded Hypertensive (FHH) rats and FHH.1BN congenic strains
Comparison
Transfer of a 4.3-Mb region of chromosome 1 from… vs FHH rats and control FHH.1 AR strain
Design
Preclinical
Follow-up
Up to 21 weeks of age
Authors
Loading...
Animal data nominate a candidate locus for renal protection in hypertension; leaves open human translation and therapeutic targeting.
Transfer of a 4.3-Mb region of BN chromosome 1 into the FHH genetic background improves autoregulation of renal blood flow, normalizes glomerular capillary pressure, and slows the progression of renal disease in a rat model.
Williams et al. (2010) studied Hypertension and renal injury. Transfer of a 4.3-Mb region of BN chromosome 1 (AR(+) strain) vs. FHH rats and control AR(-) strain was evaluated on Autoregulation of renal blood flow, glomerular capillary pressure, and protein excretion. Transfer of a 4.3-Mb region of BN chromosome 1 into the FHH genetic background improved autoregulation of renal blood flow, normalized glomerular capillary pressure, and slowed renal disease progression.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: