Key result
Transfer of a region of Brown-Norway chromosome 1 into the Fawn-hooded Hypertensive genetic background improved autoregulation of renal blood flow (AI 0.23 vs 0.80) and reduced protein excretion.
Population
Fawn-hooded Hypertensive rats, FHH.1 consomic strain, 85 F2 backcross rats, and five overlapping congenic…
Comparison
Introgression of chromosome 1 regions from the… vs FHH rats and congenic strains with other regions…
Design
Preclinical
Authors
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Identifies a chromosome 1 locus for renal autoregulation in hypertensive rats; leaves open specific genes and human translation.
Absolute Event Rate: 0.23% vs 0.8%
A gene or genes located between markers D1Mgh13 and D1Rat89 on chromosome 1 influence the autoregulation of renal blood flow and development of proteinuria in fawn-hooded hypertensive rats.
Ryan et al. (2005) studied Impaired autoregulation of renal blood flow and proteinuria (n=85). Introgression of Brown-Norway rat chromosome 1 region (D1Mgh13 to D1Rat89) vs. FHH genetic background was evaluated on Autoregulation index (AI) of renal blood flow. Transfer of a region of Brown-Norway chromosome 1 into the Fawn-hooded Hypertensive genetic background improved autoregulation of renal blood flow (AI 0.23 vs 0.80) and reduced protein excretion.
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