January 1, 1999AJP Regulatory Integrative and Comparative PhysiologyOpen Access

Impaired autoregulation of renal blood flow in the fawn-hooded rat

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Population

12-wk-old fawn-hooded hypertensive rats, fawn-hooded low blood pressure rats, and August Copenhagen Irish rats

Comparison

Elevation in renal perfusion pressure from 100… vs FHL and ACI rats (normotensive controls)

Design

Preclinical

Authors

RDRichard P.E. van DokkumUniversity Medical Center Groningen MAMagdalena Alonso‐GaliciaMerck & Co., Inc., Rahway, NJ, USA (United States)APAbraham P. ProvoostErasmus University Rotterdam

Discussion

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Implication

Impaired renal autoregulation may precede damage in hypertensive models; leaves open translation to human disease and therapies.

Structured PICO

Population

12-wk-old fawn-hooded hypertensive (FHH) rats (n=9), fawn-hooded low blood pressure (FHL) rats (n=10), and August Copenhagen Irish (ACI) rats (n=9)

Intervention

Elevation in renal perfusion pressure (RPP) from 100 to 150 mmHg

Comparator

FHL and ACI rats (normotensive controls)

Outcome

Autoregulation of renal blood flow (RBF) and autoregulatory indexessurrogate

Impaired autoregulation of renal blood flow in FHH rats precedes glomerulosclerosis and may contribute to proteinuria and renal failure in this hypertensive model.

Cite This Study

Dokkum et al. (1999) studied this question.

synapsesocial.com/papers/6a88012b4c82be800eeb382f https://doi.org/10.1152/ajpregu.1999.276.1.r189

Topics

Hypertension management

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Impaired autoregulation of renal blood flow in the fawn-hooded rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Impaired autoregulation of renal blood flow in the fawn-hooded rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider