Population
Isolated perfused hydronephrotic kidneys from hypertensive and normotensive Fawn-Hooded rats, Sprague-Dawley…
Comparison
Pressure changes and increasing concentrations… vs Sprague-Dawley and Wistar rats
Design
Preclinical
Authors
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Highlights intrinsic preglomerular resistance deficit in Fawn-Hooded rat renal susceptibility; leaves open translation to human hypertension.
A deficit in preglomerular resistance control (impaired myogenic and angiotensin II responses) is identified as a key intrinsic factor in the susceptibility of Fawn-Hooded rats to renal disease.
Rodijnen et al. (2002) studied this question.
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