Key result
FHH rats exhibited increased mean glomerular capillary hydraulic pressure (60 vs 52 mm Hg in WAG controls), correlating with early evidence of glomerular injury.
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No immediate clinical implications; leaves open translation of glomerular pressure mechanisms to human hypertensive nephropathy.
Absolute Event Rate: 60% vs 52%
Simons et al. (1993) studied focal and segmental glomerular sclerosis and chronic renal failure. FHH strain vs. WAG and FHL strains was evaluated on mean glomerular capillary hydraulic pressure. FHH rats exhibited increased mean glomerular capillary hydraulic pressure (60 vs 52 mm Hg in WAG controls), correlating with early evidence of glomerular injury.
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