Why the study?
Endoglin is associated with fibrosis across various organs, but whether it contributes to the development of interstitial fibrosis in diabetic nephropathy was unknown.
Endoglin promotes myofibroblast differentiation and extracellular matrix production, suggesting a role in the pathogenesis of interstitial fibrosis in diabetic nephropathy.
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Endoglin may associate with interstitial fibrosis in diabetic kidneys; hypothesis-generating and requires prospective validation before clinical consideration.
Gerrits et al. (2020) studied this question.
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