Why the study?
Peripheral artery disease pathophysiology includes endothelial dysfunction linked to oxidative stress via reduced nitric oxide bioavailability, but alterations in the nitric oxide system and its regulators in PAD remained to be investigated.
Are the nitric oxide system and its regulators altered in patients with peripheral artery disease and associated with oxidative stress?
Population
35 patients with intermittent claudication, 26 patients with critical limb ischemia, and 35 non-PAD controls
Comparison
Patients with intermittent claudication vs patients with critical limb ischemia vs non-PAD controls
Authors
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Oxidative stress may impair NO bioavailability in PAD; leaves open whether antioxidants improve endothelial function.
Are the nitric oxide system and its regulators altered in patients with peripheral artery disease and associated with oxidative stress?
The nitric oxide system is significantly compromised in peripheral artery disease, driven by increased oxidative stress, and worsens as the disease progresses from claudication to critical limb ischemia.
Ismaeel et al. (2020) studied this question.
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