Why the study?
PAD affects up to 200 million individuals worldwide and is often underdiagnosed, with multiple pathophysiologic pathways operating in chronic arterial ischemia of lower limbs that could improve therapeutic strategies.
Understanding the pathophysiologic pathways related to oxidative stress in PAD may help improve therapeutic strategies and patient outcomes.
Underscores PAD underdiagnosis in elderly despite ABI utility; leaves open targeted pathway interventions for CV risk reduction.
Peripheral arterial disease (PAD) is an atherosclerotic disease that affects a wide range of the world's population, reaching up to 200 million individuals worldwide. PAD particularly affects elderly individuals (>65 years old). PAD is often underdiagnosed or underestimated, although specificity in diagnosis is shown by an ankle/brachial approach, and the high cardiovascular event risk that affected the PAD patients. A number of pathophysiologic pathways operate in chronic arterial ischemia of lower limbs, giving the possibility to improve therapeutic strategies and the outcome of patients. This review aims to provide a well detailed description of such fundamental issues as physical exercise, biochemistry of physical exercise, skeletal muscle in PAD, heme oxygenase 1 (HO-1) in PAD, and antioxidants in PAD. These issues are closely related to the oxidative stress in PAD. We want to draw attention to the pathophysiologic pathways that are considered to be beneficial in order to achieve more effective options to treat PAD patients.
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Signorelli et al. (2020) studied this question.
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