Why the study?
Does amitriptyline treatment alter heart rate variability parameters in depressed patients compared to normal controls?
Population
104 depressed patients treated with amitriptyline and 52 normal control subjects matched for age and sex
Comparison
Amitriptyline (mean dosage: 163 mg/d) vs Normal control subjects matched for age and sex
Design
Case-control
Authors
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Amitriptyline effects on HRV merit consideration in depressed patients; supports marker role for TCA intake yet remains hypothesis-generating.
Does amitriptyline treatment alter heart rate variability parameters in depressed patients compared to normal controls?
Amitriptyline treatment in depressed patients is associated with significantly reduced heart rate variability and elevated heart rate, which may serve as a marker for tricyclic antidepressant intake.
Rechlin et al. (1995) studied this question.
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