Why the study?
Does paroxetine compared to amitriptyline preserve cardiovascular autonomic functions in patients with major depression?
Population
24 unmedicated patients with episodes of major depression and 24 age- and sex-matched normal subjects
Comparison
Paroxetine 20 mg oral per day for 14 days vs Amitriptyline 150 mg oral per day for 14 days
Design
RCT, randomly allocated
Follow-up
14 days
Authors
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Paroxetine preserves autonomic function better than amitriptyline in depression; confirms differential cardiovascular effects of these antidepressants.
Does paroxetine compared to amitriptyline preserve cardiovascular autonomic functions in patients with major depression?
Paroxetine preserves cardiovascular autonomic function compared to amitriptyline, suggesting it is a safer antidepressant choice for patients with or at risk for cardiovascular autonomic neuropathy.
Rechlin et al. (1994) studied this question.
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