Key result
Quetiapine augmentation was associated with significantly lower heart rate variability (total power, very low frequency, and low frequency) compared to antidepressants alone or no medication.
Why the study?
Does the use of antidepressants or quetiapine reduce heart rate variability in psychiatric patients without psychotic symptoms?
Population
94 psychiatric patients without psychotic symptoms (with depression, anxiety, or somatic symptoms)
Comparison
Antidepressants or augmentation therapy vs No antidepressant group (n=19)
Design
Cross-sectional
Authors
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Quetiapine augmentation may lower HRV; hypothesis-generating for cardiovascular risk and requires prospective studies.
Cross-Sectional (n=94)
Does the use of antidepressants or quetiapine reduce heart rate variability in psychiatric patients without psychotic symptoms?
Quetiapine augmentation, but not antidepressants alone, is associated with a significant decrease in heart rate variability in non-psychotic psychiatric patients.
Huang et al. (2016) conducted a cross-sectional in Depression, anxiety, or somatic symptoms without psychotic symptoms (n=94). Quetiapine augmentation vs. No antidepressant, SSRI, or other antidepressants was evaluated on Heart rate variability (total power, very low frequency power, and low frequency power). Quetiapine augmentation was associated with significantly lower heart rate variability (total power, very low frequency, and low frequency) compared to antidepressants alone or no medication.
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