Why the study?
Does antidepressant treatment or electroconvulsive therapy affect heart rate variability in medically well individuals with major depression?
Population
Medically well individuals with major depression (14 studies included)
Comparison
Antidepressant treatment and electroconvulsive… vs Pre-treatment baseline or within-group comparisons
Design
Meta-analysis
Authors
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Caution with TCAs in cardiac-risk depression patients; leaves open whether SSRI effects alter outcomes.
Does antidepressant treatment or electroconvulsive therapy affect heart rate variability in medically well individuals with major depression?
Tricyclic antidepressants are associated with decreased heart rate variability and increased heart rate, potentially increasing mortality risk, whereas SSRIs have weaker and more variable effects.
Zyl et al. (2008) studied this question.
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