Key result
Electroconvulsive therapy increased heart rate variability (SDNN) in patients whose depression improved (P<0.02), while low baseline HRV was associated with rapid relapse (P<0.05).
Why the study?
Does heart rate variability predict sustained response to electroconvulsive therapy in patients with depression?
Population
11 patients with depression
Design
Cohort
Follow-up
3 weeks
Authors
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HRV changes with ECT response in depression are hypothesis-generating; leaves open whether monitoring can guide treatment duration.
Observational (n=11)
Does heart rate variability predict sustained response to electroconvulsive therapy in patients with depression?
p-value: p=<0.02
Low baseline heart rate variability and lack of HRV increase during ECT are associated with rapid relapse of depression, suggesting HRV could serve as a biomarker to guide ECT treatment duration.
Karpyak et al. (2004) conducted an observational in Depression (n=11). Electroconvulsive therapy (ECT) was evaluated on Change in standard deviation of interbeat intervals (SDNN) and treatment outcome (p=<0.02). Electroconvulsive therapy increased heart rate variability (SDNN) in patients whose depression improved (P<0.02), while low baseline HRV was associated with rapid relapse (P<0.05).
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