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January 1, 2005Hypertension ResearchOpen Access

Relationships between Echocardiographic Findings, Pulse Wave Velocity, and Carotid Atherosclerosis in Type 2 Diabetic Patients

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Population

70 consecutive patients diagnosed with type 2 diabetes without cardiovascular disease, mean age 62, 48.5%…

Design

Cross-sectional

Authors

HMHisashi MasugataKagawa UniversitySSShoichi SendaTokushima Bunri UniversityKYK YoshikawaSakai Municipal Hospital

Discussion

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Overview

Echocardiographic diastolic markers may aid vascular risk evaluation in T2DM; leaves open causal and prognostic implications pending longitudinal data.

Key Points

  • The study aims to analyze the relationships between echocardiographic findings, pulse wave velocity, and carotid atherosclerosis in type 2 diabetic patients.
  • Measured pulse wave velocity using an automatic waveform analyzer in 70 type 2 diabetic patients without cardiovascular disease.
  • Obtained carotid plaque scores via carotid ultrasonography and assessed echocardiographic findings including left ventricular wall thickness and diastolic function.
  • Conducted stepwise regression analysis to identify independent associations between variables.
  • Brachial-ankle pulse wave velocity significantly correlated with carotid plaque score (r=0.37, p=0.001) and with A velocity (r=0.73, p<0.001).
  • A velocity and left ventricular wall thickness at the left ventricular outflow tract were independently associated with brachial-ankle pulse wave velocity (beta coefficients 0.42 and 0.27, respectively).
  • Left ventricular wall thickness at the outflow tract was also independently associated with the carotid plaque score (beta coefficient=0.38, p=0.001).

Structured PICO

P
Population
70 consecutive patients diagnosed with type 2 diabetes without cardiovascular disease, mean age 62, 48.5% male, based in Japan (Sakaide Municipal Hospital).
O
Outcome
Correlation between brachial-ankle pulse wave velocity, carotid plaque score, and echocardiographic parameters of left ventricular structure and diastolic functionsurrogate

In patients with type 2 diabetes, abnormal echocardiographic findings of left ventricular diastolic dysfunction and myocardial wall thickening at the outflow tract are independently associated with arterial stiffening and carotid atherosclerosis.

Limitations

  • Did not measure intima-media thickness to evaluate carotid atherosclerosis
  • Did not analyze the relationship in nondiabetic patients
  • Limitations in assessing cardiac diastolic function by left ventricular diastolic inflow patterns obtained from pulsed Doppler echocardiography (e.g., potential for pseudonormalization)

Cite This Study

Masugata et al. (2005) studied this question.

synapsesocial.com/papers/6a760ca0fa1990f79e613b42https://doi.org/10.1291/hypres.28.965
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