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January 1, 1999Japanese Circulation Journal-english EditionOpen Access

Alteration in Aortic Wall Stiffness and Accumulation of Collagen During the Prediabetic Stage of Type II Diabetes Mellitus in Rats

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Why the study?

Does the prediabetic stage of type II diabetes mellitus alter aortic wall stiffness and collagen accumulation in an OLETF rat model?

Population

30 Otsuka Long-Evans Tokushima Fatty (OLETF) rats (animal model of type II DM) and 30 nonDM rats (total n=60)

Comparison

OLETF rat model (prediabetic stage of type II DM) vs nonDM rats

Design

Preclinical

Follow-up

up to 30 weeks of age

Authors

TNTakahisa NomaKagawa UniversityKMKatsufumi MizushigeOregon Health & Science UniversityLYLi YaoChina-Japan Friendship Hospital

Discussion

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Member takes

Overview

May indicate early aortic changes in prediabetes; leaves open translation to human type 2 diabetes.

Structured PICO

Does the prediabetic stage of type II diabetes mellitus alter aortic wall stiffness and collagen accumulation in an OLETF rat model?

P
Population
30 Otsuka Long-Evans Tokushima Fatty (OLETF) rats (animal model of type II DM) and 30 nonDM rats (total n=60)
I
Intervention
OLETF rat model (prediabetic stage of type II DM)
C
Comparator
nonDM rats
O
Outcome
Aortic wall stiffness (stiffness parameter beta) and collagen (hydroxyproline) content at 15 weekssurrogate

In a rat model of type II diabetes, collagen accumulation and increased aortic wall stiffness occur even during the prediabetic stage, suggesting early vascular aging.

Cite This Study

Noma et al. (1999) studied this question.

synapsesocial.com/papers/6a7628b6b52b7ee7dcfbe17bhttps://doi.org/10.1253/jcj.63.988
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Spontaneous Long-Term Hyperglycemic Rat With Diabetic Complications: Otsuka Long-Evans Tokushima Fatty (OLETF) Strain1992 · 685 citations
  2. 2Non–Insulin-Dependent Diabetes Mellitus and Fasting Glucose and Insulin Concentrations Are Associated With Arterial Stiffness Indexes1995 · 583 citations
  3. 3Carotid Artery Intima-Media Thickness in Elderly Patients With NIDDM and in Nondiabetic Subjects1996 · 117 citations
  4. 4Aortic and large artery stiffness: Current methodology and clinical correlations1990 · 119 citations
  5. 5Evaluation of Arterial Wall Histological and Physical Characteristics Using Intravascular Echography.1992 · 9 citations