[Renal sympathetic denervation can significantly reduce blood pressure and improve arterial stiffness in hypertensive beagles].

Fuyu Ye; Guanmao Shi; X Wang; Shan Tu; Z Zhang; Lingfeng Zeng

doi:10.12122/j.issn.1673-4254.2021.11.03

November 20, 2021Open Access

[Renal sympathetic denervation can significantly reduce blood pressure and improve arterial stiffness in hypertensive beagles].

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Why the study?

The study was conducted to investigate the effect of renal sympathetic denervation on blood pressure and arterial stiffness in hypertensive beagles and explore the underlying mechanism.

Does renal sympathetic denervation reduce blood pressure and improve arterial stiffness in hypertensive beagles?

Structured PICO

Does renal sympathetic denervation reduce blood pressure and improve arterial stiffness in hypertensive beagles?

P

Population

16 purebred beagles (10-12 months old, 50% male), including a subset with hypertension induced by a high-salt high-fat diet.

I

Intervention

Renal sympathetic denervation (RDN) via radiofrequency ablation (8 W, 45-55 °C, 2 min per point, 3-4 points per side) in addition to a high-salt high-fat diet.

C

Comparator

Sham operation (renal arteriography only) with high-salt high-fat diet, and a control group fed normal formula dog food without operation.

O

Outcome

Changes in blood pressure (systolic and diastolic) and arterial stiffness (Resistance Index, RI) at 3 months post-procedure.surrogate

Renal sympathetic denervation effectively reduces blood pressure and improves arterial stiffness in a hypertensive beagle model, likely by reducing sympathetic activity and promoting NO synthesis.

Limitations

Failed to clarify the specific molecular mechanism and pathway of RDN on blood pressure and vascular function.
Failed to reveal the causal relationship between blood pressure reduction and sympathetic activity changes.
Beagles have small body size and poor vascular conditions, which may not fully reflect the true changes in human hypertensive patients.

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Implication

RDN reduces BP and arterial stiffness in hypertensive beagles; leaves open translation to human hypertension.

Abstract

OBJECTIVE: To investigate the effect of renal sympathetic denervation (RDN) on blood pressure and arterial stiffness in hypertensive beagles and explore the underlying mechanism. METHODS: =4, fed with formula dog food). The changes in blood pressure, arterial stiffness, endothelial function, and sympathetic activity were compared among the 3 groups and correlation analysis was performed. CONCLUSION: RDN can significantly reduce blood pressure and improve arterial stiffness in hypertensive beagles possibly by reducing sympathetic activity and blood pressure and promoting NO synthesis.

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Cite This Study

Ye et al. (2021) studied this question.

synapsesocial.com/papers/6a760d7f7d7eb453cc7081a7 https://doi.org/10.12122/j.issn.1673-4254.2021.11.03

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[Renal sympathetic denervation can significantly reduce blood pressure and improve arterial stiffness in hypertensive beagles].

Structured PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

[Renal sympathetic denervation can significantly reduce blood pressure and improve arterial stiffness in hypertensive beagles].

Structured PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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