Why the study?
Cardiac fibroblasts are essential for extracellular matrix homeostasis, where remodeling leads to fibrosis, and long noncoding RNAs contribute to cardiovascular development and disorders.
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Hypothesis-generating for lncPostn as post-MI fibrosis biomarker or target; human validation required before any clinical consideration.
Cardiac fibroblasts are essential for the homeostasis of the extracellular matrix, whose remodeling in many cardiovascular diseases leads to fibrosis. Long noncoding RNAs are functional and contribute to the biological processes of cardiovascular development and disorders. Our findings identify the fibroblast-enriched lncPostn as a potent profibrotic factor and demonstrate that serum lncPostn level may serve as a potential biomarker of human cardiac fibrosis postacute myocardial infarction.
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Tao et al. (2023) studied this question.
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