Key result
Non-coding RNAs influence cardiac fibrosis progression by regulating TGF-β/Smad signaling pathways.
Why the study?
Comprehensive knowledge of how non-coding RNAs affect TGF-β/Smad signaling in cardiac fibrosis may yield new diagnostic and therapeutic approaches for cardiac disorders.
Design
Review
Authors
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Hypothesis-generating for non-coding RNA-targeted therapies in cardiac fibrosis; leaves open clinical translation pending prospective studies.
Understanding the regulation of TGF-β/Smad signaling by non-coding RNAs in cardiac fibrosis may lead to novel diagnostic and therapeutic approaches for various cardiac disorders.
Saadat et al. (2021) conducted a review in Cardiac fibrosis. Non-coding RNAs, including microRNAs, long non-coding RNAs, and circular RNAs, regulate TGF-β/Smad signaling pathways to influence the development and progression of cardiac fibrosis.
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