Key result
Smad proteins mediate intracellular signaling of the TGF-β superfamily and are implicated in a wide range of cardiac disorders, including heart failure, fibrosis, and myocardial infarction.
Design
Review
Authors
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Positions Smad-TGF-β signaling as a potential therapeutic axis across cardiac disorders; leaves open validation in prospective trials.
This review highlights the role of Smad proteins and TGF-β pathways in various cardiac pathologies and structural development, suggesting potential therapeutic targets.
Yuan et al. (2010) conducted a review in Cardiac disorders. Smad proteins and TGF-β pathways was evaluated. Smad proteins mediate intracellular signaling of the TGF-β superfamily and are implicated in a wide range of cardiac disorders, including heart failure, fibrosis, and myocardial infarction.
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