Key result
Transforming growth factor β plays a central role in cardiac fibrosis, cardiomyocyte apoptosis, and hypertrophy following myocardial infarction, though therapeutic targeting has met limited success.
Design
Review
Authors
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Direct clinical translation remains elusive due to pathway complexity; leaves open the need for targeted modulation rather than.
This review highlights the complex canonical and non-canonical TGFβ signaling pathways driving cardiac fibrosis and remodeling after myocardial infarction, underscoring the challenges in therapeutically targeting this network.
Liu et al. (2017) conducted a review in Heart disease, Myocardial infarction, Cardiac fibrosis. TGFβ signaling was evaluated. Transforming growth factor β plays a central role in cardiac fibrosis, cardiomyocyte apoptosis, and hypertrophy following myocardial infarction, though therapeutic targeting has met limited success.
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