What question did this study set out to answer?

February 27, 2007Diabetes CareOpen Access

Dual Endothelin Receptor Blockade Acutely Improves Insulin Sensitivity in Obese Patients With Insulin Resistance and Coronary Artery Disease

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Why the study?

Does dual endothelin receptor blockade improve insulin sensitivity in obese patients with insulin resistance and coronary artery disease?

Population

7 obese patients (aged 58 +/- 2 years) with insulin resistance and coronary artery disease

Comparison

Selective ET receptor blockade and dual ET+ET… vs Control clamp (saline infusion)

Design

Other

Follow-up

acute

Authors

GAG. AhlborgSödertörn University ASAlexey ShemyakinKola Science Centre FBFelix BöhmInterventional Cardiology

Discussion

Member takes

Implication

Acute dual ET blockade may enhance insulin sensitivity; leaves open therapeutic translation in obese CAD patients.

Key Points

To determine whether selective ET(A) or combined ET(A) and ET(B) receptor blockade acutely improves insulin sensitivity in patients with insulin resistance and coronary artery disease.
Seven patients (aged 58 ± 2 years) with insulin resistance and coronary artery disease completed three hyperinsulinemic-euglycemic clamp protocols.
The three experimental conditions comprised a saline control clamp, selective ET(A) blockade with BQ123, and dual ET(A) plus ET(B) blockade with BQ123 and BQ788.
Total-body glucose uptake, splanchnic blood flow, and renal blood flow were measured via dye dilution and p-aminohippurate infusion.
Total-body glucose uptake was highest during dual ET(A) and ET(B) blockade (P < 0.05), with insulin-corrected uptake significantly higher than control (P < 0.01) and selective ET(A) blockade (P < 0.05).
Mean arterial pressure decreased significantly under both selective ET(A) blockade (P < 0.01) and dual blockade (P < 0.05), whereas it remained unchanged during the control clamp.
Renal blood flow increased and renal vascular resistance declined exclusively during dual blockade (P < 0.05), with neither intervention altering splanchnic blood flow.

Structured PICO

Does dual endothelin receptor blockade improve insulin sensitivity in obese patients with insulin resistance and coronary artery disease?

Population

7 obese patients (aged 58 +/- 2 years) with insulin resistance and coronary artery disease

Intervention

Selective ET(A) receptor blockade (BQ123) and dual ET(A)+ET(B) receptor blockade (BQ123 + BQ788) during hyperinsulinemic-euglycemic clamp protocols

Comparator

Control clamp (saline infusion)

Outcome

Total-body glucose uptake (M) and M value corrected by insulinsurrogate

Dual endothelin receptor blockade acutely improves insulin sensitivity in obese patients with insulin resistance and coronary artery disease, highlighting the role of endogenous ET-1.

Cite This Study

Ahlborg et al. (2007) studied this question.

synapsesocial.com/papers/6a760f4549a8cdd61fb1eec6 https://doi.org/10.2337/dc06-1978

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Dual Endothelin Receptor Blockade Acutely Improves Insulin Sensitivity in Obese Patients With Insulin Resistance and Coronary Artery Disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Dual Endothelin Receptor Blockade Acutely Improves Insulin Sensitivity in Obese Patients With Insulin Resistance and Coronary Artery Disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

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