August 1, 1990Journal of Biological ChemistryOpen Access

Metabolism of endothelial cell-bound lipoprotein lipase. Evidence for heparan sulfate proteoglycan-mediated internalization and recycling.

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Population

Cultured porcine aortic endothelial cells

Design

Preclinical

Authors

USUday SaxenaIndian Institute of Technology Hyderabad MKMichal KleinIsrael Institute for Biological Research IGIra J. GoldbergPreventive Cardiology

Discussion

Member takes

Implication

May sustain endothelial LPL activity in lipid handling; leaves open relevance to human cardiovascular risk.

Structured PICO

Population

Cultured porcine aortic endothelial cells

Intervention

Incubation with purified radioiodinated bovine lipoprotein lipase (LPL) under various conditions (temperature, heparin, heparinase, pH)

Outcome

LPL binding, internalization, and recycling dynamicssurrogate

Endothelial cells internalize and recycle lipoprotein lipase via a heparan sulfate proteoglycan-mediated mechanism, maintaining its catalytic activity.

Cite This Study

Saxena et al. (1990) studied this question.

synapsesocial.com/papers/6a761164881b59604d613e71 https://doi.org/10.1016/s0021-9258(19)38242-0

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Metabolism of endothelial cell-bound lipoprotein lipase. Evidence for heparan sulfate proteoglycan-mediated internalization and recycling.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Metabolism of endothelial cell-bound lipoprotein lipase. Evidence for heparan sulfate proteoglycan-mediated internalization and recycling.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider